• Medicine
  • Published in
    The Journal of biological…
    2002

Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells.

@article{Liu2002InvolvementOB,
  title={Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells.},
  author={Fujun Liu and Isao Usui and Lui Guojing Evans and Darrell A. Austin and Pamela L Mellon and Jerrold M. Olefsky and Nicholas J G Webster},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 35},
  pages={
          32099-108
        }
}
The hypothalamic hormone gonadotropin-releasing hormone (GnRH) stimulates the synthesis and release of the pituitary gonadotropins. GnRH acts through a plasma membrane receptor that is a member of the G protein-coupled receptor (GPCR) family. These receptors interact with heterotrimeric G proteins to initiate downstream signaling. In this study, we have investigated which G proteins are involved in GnRH receptor-mediated signaling in L beta T2 pituitary gonadotrope cells. We have shown… CONTINUE READING

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