Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells.

@article{Inagaki2006InvolvementOB,
  title={Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells.},
  author={Kenichi Inagaki and Fumio Otsuka and Jiro Suzuki and Yoshihiro Kano and Masaya Takeda and Tomoko Miyoshi and Hiroyuki Otani and Yukari Mimura and Toshio Ogura and Hirofumi Makino},
  journal={Endocrinology},
  year={2006},
  volume={147 6},
  pages={2681-9}
}
Aldosterone production is modified by several growth factors that reside in the adrenal. We have recently reported the existence of a bone morphogenetic protein (BMP) system in human adrenocortical cells, in which BMP-6 augments aldosterone synthesis. Here, we investigated functional roles of BMP-6, focusing on the differential regulation of aldosterone synthesis induced by angiotensin (Ang) II and potassium (K). In human adrenocortical H295R cells, BMP-6 augmented Ang II-induced CYP11B2… CONTINUE READING

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