Involvement of beta-endorphin and mu-opioid receptors in mediating the aversive effect of lithium in the rat.

@article{Shippenberg1988InvolvementOB,
  title={Involvement of beta-endorphin and mu-opioid receptors in mediating the aversive effect of lithium in the rat.},
  author={T. S. Shippenberg and M. J. Millan and Ronald F. Mucha and A. Herz},
  journal={European journal of pharmacology},
  year={1988},
  volume={154 2},
  pages={135-44}
}
The role of beta-endorphin and mu-opioid receptors in mediating the motivational effect of lithium was examined by use of an unbiased place-preference conditioning procedure. Administration of lithium to drug-naive rats resulted in a dose-related aversion for the drug-associated place. Radiofrequency lesions of the medio-basal arcuate hypothalamus, which markedly reduced the levels of immunoreactive beta-endorphin in the hypothalamus, abolished the lithium-induced aversion. However, suppression… CONTINUE READING

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