Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration

Abstract

Lysophosphatidic acid (LPA) has a critical role in lymphocyte migration to secondary lymphoid organs. Autotaxin (ATX)/lysophospholipase D, in the vascular endothelium, is the main enzyme involved in LPA production. Whether ATX is involved in pathological lymphocyte migration to the inflamed mucosa has not been studied. We investigated the involvement of ATX… (More)
DOI: 10.1038/labinvest.2013.45

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@article{Hozumi2013InvolvementOA, title={Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration}, author={Hideaki Hozumi and Ryota Hokari and Chie Kurihara and Kazuyuki Narimatsu and Hirokazu Sato and Shingo Sato and Toshihide Ueda and Masaaki Higashiyama and Yoshikiyo Okada and Chikako Watanabe and Shunsuke Komoto and Kengo Tomita and Atsushi Kawaguchi and Shigeaki Nagao and S. Miura}, journal={Laboratory Investigation}, year={2013}, volume={93}, pages={508-519} }