Involvement of apolipoprotein E in glioblastoma: immunohistochemistry and clinical outcome.

@article{Nicoll2003InvolvementOA,
  title={Involvement of apolipoprotein E in glioblastoma: immunohistochemistry and clinical outcome.},
  author={James A. R. Nicoll and Elena Zunarelli and Roy Rampling and Lilian S. Murray and Vakis Papanastassiou and Janice Stewart},
  journal={Neuroreport},
  year={2003},
  volume={14 15},
  pages={1923-6}
}
We hypothesised that apolipoprotein E (apoE) influences brain tumours by delivery of lipids to tumour cells and by analogy with other brain insults. APOE gene analysis was performed for 126 glioblastomas, the commonest primary brain tumour. Neither APOE epsilon2 nor epsilon4 alleles were significantly associated with differences in post-operative survival. However, there was apoE immunoreactivity of tumour cells, macrophages in areas of necrosis and astrocytes nearby. The immunohistochemistry… CONTINUE READING