Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.

@article{Aires1999InvolvementOA,
  title={Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.},
  author={Julio Ramos Aires and Thilo K{\"o}hler and Hiroshi Nikaido and Patrick Pl{\'e}siat},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 11},
  pages={2624-8}
}
A mutant, named 11B, hypersusceptible to aminoglycosides, tetracycline, and erythromycin was isolated after Tn501 insertion mutagenesis of Pseudomonas aeruginosa PAO1. Cloning and sequencing experiments showed that 11B was deficient in an, at that time, unknown active efflux system that contains homologs of MexAB. This locus also contained a putative regulatory gene, mexZ, transcribed divergently from the efflux operon. Introduction of a recombinant plasmid that carries the genes of the efflux… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
113 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 113 extracted citations

Similar Papers

Loading similar papers…