Involvement of an Upstream Stimulatory Factor as Well as cAMP-responsive Element-binding Protein in the Activation of Brain-derived Neurotrophic Factor Gene Promoter I*

@article{Tabuchi2002InvolvementOA,
  title={Involvement of an Upstream Stimulatory Factor as Well as cAMP-responsive Element-binding Protein in the Activation of Brain-derived Neurotrophic Factor Gene Promoter I*},
  author={Akiko Tabuchi and Hidemichi Sakaya and Tomochika Kisukeda and Hiroshi Fushiki and Masaaki Tsuda},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={35920 - 35931}
}
The use of different brain-derived neurotrophic factor (BDNF) gene promoters results in the differential production of 5′-alternative transcripts, suggesting versatile functions of BDNF in neurons. Among four BDNF promoters I, II, III, and IV (BDNF-PI, -PII, -PIII, and -PIV), BDNF-PI was markedly activated, as well as BDNF-PIII, by Ca2+ signals evoked via neuronal activity. However, little is known about the mechanisms for the transcriptional activation of BDNF-PI. Using rat cortical neurons in… 
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Robust stimulation of TrkB autonomously induces delayed BDNF mRNA expression in an activity‐dependent manner in rat cortical neurons, resulting in the stimulation of Arc mRNA expression through endogenously synthesized BDNF, the process being orchestrated by the Ca2+ and ERK/MAPK signaling pathways.
Upstream Stimulatory Factors Are Mediators of Ca2+-Responsive Transcription in Neurons
TLDR
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TLDR
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