Involvement of adiponectin in the pathogenesis of dystrophinopathy

@inproceedings{AbouSamra2015InvolvementOA,
  title={Involvement of adiponectin in the pathogenesis of dystrophinopathy},
  author={Michel Abou-Samra and Sophie Lecompte and Olivier Schakman and Laurence Noel and Marie C. Many and Philippe Gailly and Sonia M. Brichard},
  booktitle={Skeletal Muscle},
  year={2015}
}
The hormone adiponectin (ApN) is decreased in the metabolic syndrome, where it plays a key pathogenic role. ApN also exerts some anti-inflammatory effects on skeletal muscles in mice exposed to acute or chronic inflammation. Here, we investigate whether ApN could be sufficiently potent to counteract a severe degenerative muscle disease, with an inflammatory component such as Duchenne muscular dystrophy (DMD). Mdx mice (a DMD model caused by dystrophin mutation) were crossed with mice… CONTINUE READING
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