Involvement of adipokines in rimonabant-mediated insulin sensitivity in ob/ob mice.


OBJECTIVES It has been recently reported that blockade of type 1 cannabinoid (CB1) receptors by specific antagonists or genetic manipulation alleviates dyslipidaemia, hyperglycaemia and insulin resistance in animal models of obesity and type 2 diabetes. However, the precise role of adipokines in the insulin-sensitising effects of the CB1 antagonist… (More)
DOI: 10.1211/jpp/61.11.0008