Involvement of adhesion molecules LFA-1 and ICAM-1 in osteoclast development.

@article{Kurachi1993InvolvementOA,
  title={Involvement of adhesion molecules LFA-1 and ICAM-1 in osteoclast development.},
  author={Toshiaki Kurachi and Ikuo Morita and Sei-itsu Murota},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1178 3},
  pages={
          259-66
        }
}
We report here that leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) are involved in osteoclast development. Osteoclast development was observed on co-culture of mouse spleen cells and mouse bone marrow derived clonal stromal cells, TMS-14, in the presence of 1 alpha, 25-dihydroxyvitamin D-3 (1 alpha, 25-(OH)2D3) for 8 days, and quantified with respect to tartrate-resistant acid phosphatase (TRACP) activity. When either one of the monoclonal… CONTINUE READING
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