Involvement of adenosinergic receptors in anxiety related behaviours.

  title={Involvement of adenosinergic receptors in anxiety related behaviours.},
  author={Shrinivas Krishnarao Kulkarni and Kulwinder Singh and Mahendra Bishnoi},
  journal={Indian journal of experimental biology},
  volume={45 5},
In the present study, the effect of adenosine (A1 and A2 receptor agonist), caffeine (A2A receptor antagonist), theophylline (A2A receptor antagonist) and their combination was studied in anxiety related behaviours using elevated zero maze and elevated plus maze paradigms and compared their various behavioural profiles. Adenosine (10, 25, 50,100 mg/kg) significantly showed anxiolytic effect at all the doses, whereas caffeine (8, 15, 30, 60 mg/kg) and theophylline (30, 60 mg/kg) showed… CONTINUE READING