Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: dissociation from gastrointestinal effects in mice.

@article{Delander1992InvolvementOA,
  title={Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: dissociation from gastrointestinal effects in mice.},
  author={Gary E Delander and Henry I. Mosberg and Frank Porreca},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={263 3},
  pages={
          1097-104
        }
}
Possible involvement of adenosine, as a secondary neurotransmitter, in opioid modulation of nociception and gastrointestinal function was investigated in mice. Inhibitory actions of theophylline, a nonselective adenosine receptor antagonist, were evaluated against effects evoked by opioid receptor-selective agonists administered at spinal or supraspinal sites. Intrathecal administration of theophylline significantly inhibited antinociceptive actions produced by intrathecal (i.th.) injections of… CONTINUE READING

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