Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine

@article{Filip2006InvolvementOA,
  title={Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine},
  author={M. Filip and M. Frankowska and M. Zaniewska and E. Przegaliński and K. Fuxe},
  journal={Brain Research},
  year={2006},
  volume={1077},
  pages={67-80}
}
  • M. Filip, M. Frankowska, +2 authors K. Fuxe
  • Published 2006
  • Chemistry, Medicine
  • Brain Research
  • Recent data indicate that cocaine locomotor responses may be influenced by dopamine (DA) neurotransmission and adenosine neuromodulation involving the A2A receptor (A2AR). Male Wistar rats were injected with MSX-3 (1-25 mg/kg; an antagonist of A2AR), CGS 21680 (0.05-0.2 mg/kg; an agonist of A2AR), SCH 23390 (0.125-0.25 mg/kg; an antagonist of DA D1/5R), raclopride (0.1-0.8 mg/kg; an antagonist of DA D2/3R), nafadotride (0.2-0.4 mg/kg; an antagonist of DA D3R) or 7-OH-PIPAT (0.01-1 mg/kg; an… CONTINUE READING
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