Involvement of adenosine 5'-triphosphate in ultrasound-induced fracture repair.

  title={Involvement of adenosine 5'-triphosphate in ultrasound-induced fracture repair.},
  author={Michael John Hayton and Jane P. Dillon and Danielle J. Glynn and Judith M. Curran and James A. Gallagher and Katherine A. Buckley},
  journal={Ultrasound in medicine & biology},
  volume={31 8},
Ultrasound (US) accelerates fracture healing; however, the mechanism of this effect remains unclear. Adenosine 5'-triphosphate (ATP) stimulates bone remodeling and is released constitutively from intact osteoblasts; this is a process that is enhanced after mechanical stimulation. We hypothesized that ATP release from osteoblasts is increased after US stimulation and that this leads to accelerated fracture healing. US was applied to SaOS-2 human osteoblasts and the concentration of ATP in the… CONTINUE READING

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