Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS

@article{Linghu2006InvolvementOA,
  title={Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS},
  author={Hua Linghu and Masahiro Tsuda and Yuichi Makino and Mieko Sakai and Tsuyoshi Watanabe and Shin Ichihara and H Sawa and Kumiko Nagashima and Naoki Mochizuki and Shinya Tanaka},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={3547-3556}
}
Signaling adaptor protein Crk regulates cell motility and growth through its targets Dock180 and C3G, those are the guanine-nucleotide exchange factors (GEFs) for small GTPases Rac and Rap, respectively. Recently, overexpression of Crk has been reported in various human cancers. To define the role for Crk in human cancer cells, Crk expression was targeted in the human ovarian cancer cell line MCAS through RNA interference, resulting in the establishment of three Crk knockdown cell lines. These… CONTINUE READING