Involvement of activated periglomerular leukocytes in the rupture of Bowman's capsule and glomerular crescent progression in experimental glomerulonephritis.

@article{Lan1992InvolvementOA,
  title={Involvement of activated periglomerular leukocytes in the rupture of Bowman's capsule and glomerular crescent progression in experimental glomerulonephritis.},
  author={Han Y. Lan and David J Nikolic-Paterson and Robert C. Atkins},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1992},
  volume={67 6},
  pages={743-51}
}
BACKGROUND In an experimental model of crescentic glomerulonephritis, we have investigated whether periglomerular leukocytes are involved in (a), the disruption of Bowman's capsule (BC), and (b) the progression of cellular crescents. EXPERIMENTAL DESIGN Experimental crescentic glomerulonephritis was induced in inbred Sprague-Dawley rats using passive accelerated anti-glomerular basement membrane disease. Groups of 4 animals were sacrificed at 3, 7, 14, 21, and 28 days after administration of… CONTINUE READING

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