Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.

@article{Liu2002InvolvementOA,
  title={Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.},
  author={Fei Liu and Khalid Iqbal and Inge Grundke-Iqbal and C L Gong},
  journal={FEBS letters},
  year={2002},
  volume={530 1-3},
  pages={209-14}
}
Microtubule-associated protein tau is abnormally hyperphosphorylated, glycosylated, and aggregated in affected neurons in the brains of individuals with Alzheimer's disease (AD). We recently found that the glycosylation might precede hyperphosphorylation of tau in AD. In this study, we investigated the effect of glycosylation on phosphorylation of tau catalyzed by cyclin-dependent kinase 5 (cdk5) and glycogen synthase kinase-3beta (GSK-3beta). The phosphorylation of the longest isoform of… CONTINUE READING
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