Involvement of a small GTP binding protein in HIV-1 release


There is evidence suggesting that actin binding to HIV-1 encoded proteins, or even actin dynamics themselves, might play a key role in virus budding and/or release from the infected cell. A crucial step in the reorganisation of the actin cytoskeleton is the engagement of various different GTP binding proteins. We have thus studied the involvement of GTP-binding proteins in the final steps of the HIV-1 viral replication cycle. Our results demonstrate that virus production is abolished when cellular GTP binding proteins involved in actin polymerisation are inhibited with specific toxins. We propose a new HIV budding working model whereby Gag interactions with pre-existing endosomal cellular tracks as well as with a yet non identified element of the actin polymerisation pathway are required in order to allow HIV-1 to be released from the infected cell.

DOI: 10.1186/1742-4690-2-48

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@article{Audoly2005InvolvementOA, title={Involvement of a small GTP binding protein in HIV-1 release}, author={Gilles Audoly and Michel Robert Popoff and Pablo Gluschankof}, journal={Retrovirology}, year={2005}, volume={2}, pages={48 - 48} }