Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling.

@article{Matsuno2002InvolvementOA,
  title={Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling.},
  author={Kenji Matsuno and Masahiro Ito and Kazuya Hori and Fumiyasu Miyashita and Satoshi Suzuki and Noriyuki Kishi and Spyros Artavanis-Tsakonas and Hideyuki Okano},
  journal={Development},
  year={2002},
  volume={129 4},
  pages={
          1049-59
        }
}
The Notch pathway is an evolutionarily conserved signaling mechanism that is essential for cell-cell interactions. The Drosophila deltex gene regulates Notch signaling in a positive manner, and its gene product physically interacts with the intracellular domain of Notch through its N-terminal domain. Deltex has two other domains that are presumably involved in protein-protein interactions: a proline-rich motif that binds to SH3-domains, and a RING-H2 finger motif. Using an overexpression assay… CONTINUE READING

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