Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system.

@article{Okumura2006InvolvementOA,
  title={Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system.},
  author={Akiko Joo Okumura and Kiyotaka Hatsuzawa and Taku Tamura and Hisao Nagaya and Kazuko Saeki and Fumihiko Okumura and Kenji Nagao and Mitsuo Nishikawa and Akihiko Yoshimura and Ikuo Wada},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 7},
  pages={4495-506}
}
The cellular endomembrane system requires the proper kinetic balance of synthesis and degradation of its individual components, which is maintained in part by a specific membrane fusion apparatus. In this study, we describe the molecular properties of D12, which was identified from a mouse expression library. This C-terminal anchored membrane protein has sequence similarity to both a yeast soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE), Use1p/Slt1p, and a… CONTINUE READING