Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation.

@article{Hildreth1989InvolvementOA,
  title={Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation.},
  author={James E. K. Hildreth and Rimas J. Orentas},
  journal={Science},
  year={1989},
  volume={244 4908},
  pages={1075-8}
}
Cell fusion (syncytium formation) is a major cytopathic effect of infection by human immunodeficiency virus (HIV) and may also represent an important mechanism of CD4+ T-cell depletion in individuals infected with HIV. Syncytium formation requires the interaction of CD4 on the surface of uninfected cells with HIV envelope glycoprotein gp120 expressed on HIV-infected cells. However, several observations suggest that molecules other than CD4 play a role in HIV-induced cell fusion. The leukocyte… CONTINUE READING