Involvement of a gene on chromosome 9 in human fibroblast Interferon production

@article{Meager1979InvolvementOA,
  title={Involvement of a gene on chromosome 9 in human fibroblast Interferon production},
  author={Anthony Meager and H E Graves and Derek C. Burke and Dallas M. Swallow},
  journal={Nature},
  year={1979},
  volume={280},
  pages={493-495}
}
HUMAN fibroblast interferon is a single monomeric gly-coprotein1, and presumably a single structural gene codes for the human interferon polypeptide. It was originally reported that chromosomes 2 and 5 were necessary together for human interferon production2. More recent evidence suggests that both chromosomes 2 and 5 carry separate human interferon genes3,4. However, we have found, in two separate series of human–mouse somatic cell hybrid cell lines and their diphtheria toxin-resistant… Expand
[65] Methods for mapping human interferon structural genes
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The chapter describes theInterferon induction and assay procedures that routinely use for studying interferon synthesis in somatic cell hybrids and the major techniques and findings in the mapping of genes governing human Interferon production. Expand
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A cDNA clone for human immune interferon (IFN-gamma) gene sequences, plasmid p69, was used to chromosomally map the IFN-gamma gene by detecting human IFN-gamma gene sequences in DNA isolated fromExpand
SOMATIC CELL GENETIC ANALYSIS OF INTERFERON PRODUCTION AND RESPONSE *
TLDR
Recent work with somatic cell hybrids is discussed to further elucidate the genetic control behind interferon systhesis and response and to discuss the roles played by each of these chromosomes. Expand
Human beta interferon gene localization and expression in somatic cell hybrids
The human fibroblast interferon gene beta 1 was mapped to human chromosome 9. Sequence homology with a beta 1 cDNA clone was detected in both genomic DNA and induced mRNA of human/mouse orExpand
Mapping of murine Interferon-α genes to chromosome 4
TLDR
A cDNA library was constructed from polysomal poly(A) + RNA from Newcastle disease virus (NDV)-induced mouse C243 cells, and screened with a human interferon-a (HuIFN-α) cDNA probe and revealed a partial copy which is almost identical to the published sequence for the MuIFn-α2 gene. Expand
Interferon-beta-related DNA is dispersed in the human genome.
TLDR
The finding that DNA related to theIFN-beta 1 gene (and IFN-alpha 1 gene) is dispersed in the human genome raises new questions about the origins of the interferon genes. Expand
Clustering of leukocyte and fibroblast interferon genes of human chromosome 9.
TLDR
Gene mapping was accomplished by blot hybridization of cloned interferon complementary DNA to DNA from human-mouse cell hybrids with a translocation involving human chromosome 9. Expand
A comparison of vertebrate interferon gene families detected by hybridization with human interferon DNA.
TLDR
Detailed restriction endonuclease mapping of DNA sequences neighbouring the interferon-beta gene in a variety of primates indicated a strong evolutionary conservation of flanking sequences, particularly on the 3' side of the gene. Expand
Heterogeneity of poly(I).poly(C)-induced human fibroblast interferon mRNA species
TLDR
It is shown here, using gel electrophoresis of mRNA, that two populations of translationally active human fibroblast IFN mRNA molecules exist—an abundant ‘14 S’ species and a scarce ‘11 S” species. Expand
Mouse interferon alpha and beta genes are linked at the centromere proximal region of chromosome 4.
TLDR
Southern blot analysis of DNA from mouse/hamster hybrids compared with the analysis of chromosome markers showed that both the MuIFN-alpha and the MuifN-beta genes are located on chromosome 4. Expand
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