Involvement of a DNA binding protein, MDR-NF1/YB-1, in human MDR1 gene expression by actinomycin D.

@article{Asakuno1994InvolvementOA,
  title={Involvement of a DNA binding protein, MDR-NF1/YB-1, in human MDR1 gene expression by actinomycin D.},
  author={K Asakuno and Kimitoshi Kohno and Takeshi Uchiumi and Toshikazu Kubo and Shinichi Sato and Masato Isono and Michihiko Kuwano},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={199 3},
  pages={1428-35}
}
The human multidrug resistance 1 (MDR1) gene is an SOS gene that responds to environmental stress including various anticancer agents. The chloramphenicol acetyltransferase (CAT) gene was linked to various lengths of MDR1 promoter, and these constructs were integrated into the genome of human cancer KB cells. Using these cell lines, we previously… CONTINUE READING