Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation

@inproceedings{Bchle2015InvolvementOA,
  title={Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation},
  author={Susanna M. B{\"a}chle and Daniel Sauter and Sabrina Sibitz and Johan K Sandberg and Frank Kirchhoff and Markus Moll},
  booktitle={Scientific reports},
  year={2015}
}
The HIV-1 accessory protein Vpu is emerging as a critical factor for viral evasion from innate immunity. We have previously shown that the Vpu proteins of two HIV-1 group M subtype B strains (NL4-3 and BaL) down-regulate CD1d from the surface of infected dendritic cells (DCs) and inhibit their crosstalk with the innate invariant natural killer T (iNKT) cells. In the present study, we have investigated the ability of a comprehensive set of primate lentiviral Vpu proteins to interfere with CD1d… CONTINUE READING
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