Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers

@article{Sato2007InvolvementOU,
  title={Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers},
  author={Masanobu Sato and T. Iwanaga and Hideaki Mamada and T. Ogihara and H. Yabuuchi and Tomoji Maeda and I. Tamai},
  journal={Pharmaceutical Research},
  year={2007},
  volume={25},
  pages={639-646}
}
PurposeTo examine the mechanisms of the alteration of serum uric acid level by angiotensin II receptor blockers (ARBs), the effects of ARBs on renal uric acid transporters, including OAT1, OAT3, OAT4, and MRP4, were evaluated.Materials and MethodsUptakes of uric acid by OAT1-expressing Flp293 cells, by Xenopus oocytes expressing OAT3 or OAT4, and by membrane vesicles from Sf9 cells expressing MRP4 were evaluated in the presence or absence of ARBs.ResultsAll ARBs inhibited uptake of uric acid or… Expand
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