Involvement of UDP-Glucuronosyltransferases in the Extensive Liver and Intestinal First-Pass Metabolism of Flavonoid Baicalein

Abstract

The present study aims to investigate the involvement of UDP-glucuronosyltranferase (UGT) in the extensive liver and intestinal first-pass glucuronidation of baicalein (B) in both rats and humans and also to study sulfation and P450 mediated hydroxylation of B. B was incubated with liver and intestine microsome, cytosol, S9 fractions from human, rat and… (More)
DOI: 10.1007/s11095-006-9126-y

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