Involvement of Trp-284, Val-296, and Val-297 of the human delta-opioid receptor in binding of delta-selective ligands.

@article{Valiquette1996InvolvementOT,
  title={Involvement of Trp-284, Val-296, and Val-297 of the human delta-opioid receptor in binding of delta-selective ligands.},
  author={M Valiquette and Huy Khang Vu and S. Y. Yue and Claes Wahlestedt and Patrick N Walker},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 31},
  pages={18789-96}
}
Given the high homology in amino acid sequence between the delta-opioid receptor and the two other types (mu and kappa), distinct residues in this receptor may confer its selectivity to some ligands. In order to identify molecular determinants in the human delta receptor responsible for the selectivity of delta-selective ligands, two different delta/mu chimeras were constructed. In the first one, the delta sequence from the top of transmembrane 5 to the C terminus was replaced by the equivalent… CONTINUE READING

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