Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury.

@article{Higuchi2012InvolvementOT,
  title={Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury.},
  author={Satonori Higuchi and Masanori Kobayashi and Azusa Yano and Koichi Tsuneyama and Tatsuki Fukami and Miki Nakajima and Tsuyoshi Yokoi},
  journal={Journal of applied toxicology : JAT},
  year={2012},
  volume={32 10},
  pages={815-22}
}
Drug-induced liver injury is a growing concern for pharmaceutical companies and patients because numerous drugs have been linked to hepatotoxicity and it is the most common reason for a drug to be withdrawn. Flutamide rarely causes liver dysfunction in humans, and immune allergic reactions have been suggested in some cases. In this study, we investigated the mechanisms of flutamide-induced liver injury in BALB/c mice. Plasma alanine aminotransferase and aspartate aminotransferase levels were… CONTINUE READING
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