Involvement of TRPA1 activation in acute pain induced by cadmium in mice

  title={Involvement of TRPA1 activation in acute pain induced by cadmium in mice},
  author={Saeko Miura and Kenji Takahashi and Toshiaki Imagawa and Kunitoshi Uchida and Shigeru Saito and Makoto Tominaga and Toshio Ohta},
  booktitle={Molecular pain},
BACKGROUND Cadmium (Cd) is an environmental pollutant and acute exposure to it causes symptoms related to pain and inflammation in the airway and gastrointestinal tract, but the underlying mechanisms are still unclear. TRPA1 is a nonselective cation channel expressed in sensory neurons and acts as a nociceptive receptor. Some metal ions such as Ca, Mg, Ba and Zn are reported to modulate TRPA1 channel activity. In the present study, we investigated the effect of Cd on cultured mouse dorsal root… CONTINUE READING
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Robles-Osorio ML: Renal health and the environment: heavy metal nephrotoxicity

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