Involvement of T lymphocytes in curative effect of a new immunomodulator OM 163 on rat colon cancer metastases.

@article{Onier1993InvolvementOT,
  title={Involvement of T lymphocytes in curative effect of a new immunomodulator OM 163 on rat colon cancer metastases.},
  author={Nathalie Onier and Pascale Lejeune and Maureen K. Martin and Arlette Hammann and Jacqui Bauer and P C Hirt and Patricia Lagadec and Jean François Jeannin},
  journal={European journal of cancer},
  year={1993},
  volume={29A 14},
  pages={2003-9}
}
In a model of colon cancer in syngeneic rats, a new immunomodulator, OM 163, induced the complete disappearance of peritoneal carcinomatosis (nodules measuring 1-5 mm) in 41 out of 82 rats. Those results were confirmed in a survival experiment in which 3 out of 10 treated rats died free of tumour 10, 18 and 28 months after the tumour cell injection while all the untreated control rats died of their tumours within 3 months. OM 163 had a systemic effect, since injected intraperitoneally it… CONTINUE READING