Involvement of Sp1 in the transcriptional regulation of the rat insulin-like growth factor-1 gene.

Abstract

UNLABELLED Most insulin-like growth factor-I (IGF-I) transcripts are initiated in exon 1, but mechanisms of regulation are not well understood. Since potential Sp1 sites are found in footprinted regions within approximately 360 bp upstream and downstream from the major initiation sites in exon 1, we explored the involvement of Sp1 and Sp3 in regulation of… (More)

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