Involvement of Sp1 in lipopolysaccharide-induced expression of HDC mRNA in RAW 264 cells.

  title={Involvement of Sp1 in lipopolysaccharide-induced expression of HDC mRNA in RAW 264 cells.},
  author={N. Hirasawa and Masashi Torigoe and K. Kano and K. Ohuchi},
  journal={Biochemical and biophysical research communications},
  volume={349 2},
  • N. Hirasawa, Masashi Torigoe, +1 author K. Ohuchi
  • Published 2006
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • The involvement of Sp1 in the lipopolysaccharide (LPS)-induced transcription of HDC mRNA in the mouse macrophage-like cell line RAW 264 was analyzed. LPS increased the levels of HDC mRNA 4 h after the stimulation in a concentration-dependent manner. Mithramycin A, an inhibitor of the binding of the Sp family to the GC box, reduced the LPS-induced increase in the levels of HDC mRNA at 4 h and HDC protein at 8 h in a concentration-dependent manner. By conducting electrophoretic mobility shift… CONTINUE READING
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