Involvement of Sp-1 in the regulation of the Id-1 gene during trophoblast cell differentiation.

@article{Takeda2007InvolvementOS,
  title={Involvement of Sp-1 in the regulation of the Id-1 gene during trophoblast cell differentiation.},
  author={Takashi Takeda and Masatoshi Sakata and Aki Isobe and Tadashi Yamamoto and Fumihito Nishimoto and Ryoko Minekawa and Masako Hayashi and Yoshitaka Okamoto and P-Y Desprez and Kachio Tasaka and Yukihito Murata},
  journal={Placenta},
  year={2007},
  volume={28 2-3},
  pages={192-8}
}
Id-1, a member of the helix-loop-helix transcription factor family, inhibits the differentiation of Rcho-1 cells, which were derived from rat choriocarcinoma and consist of trophoblast stem cells. Id-1 is expressed at a high level in undifferentiated trophoblast stem cells and then down-regulated during early differentiation, and is thought to be a key regulator in the trophoblast giant-cell differentiation pathway. In this study, we analyzed the signaling mechanism regulating the high… CONTINUE READING