Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.

  title={Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.},
  author={Kimiyo N. Yamamoto and Shunsuke Kobayashi and Masataka Tsuda and Hitoshi Kurumizaka and Minoru Takata and Koichi Kono and Josef Jiricny and Shunichi Takeda and Kouji Hirota},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 16},
Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs processing involves the Fanconi anemia (FA) pathway and homologous recombination. Stalled replication forks activate the eight-subunit FA core complex, which ubiquitylates FANCD2-FANCI. Once it is posttranslationally modified, this heterodimer recruits downstream members of the ICL repairosome, including the FAN1 nuclease. However, ICL processing has been shown to also… CONTINUE READING
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Disruption of mouse Slx 4 , a regulator of structurespeci fi c nucleases , phenocopies Fanconi anemia

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  • Nat Genet
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Mutations of the SLX4 gene in Fanconi anemia

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