Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes

@inproceedings{Zhou2011InvolvementOR,
  title={Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes},
  author={Hong Zhou and Yongjun Li and Mian Wang and Lihui Zhang and Bing-yan Guo and Zhan-sheng Zhao and Feng-ling Meng and Yong-gui Deng and Rui-ying Wang},
  booktitle={Acta Pharmacologica Sinica},
  year={2011}
}
Aim:To investigate whether activation of RhoA/Rho kinase (ROCK) is involved in myocardial fibrosis in diabetic hearts.Methods:A rat model of type 2 diabetes was established using high fat diet combined with streptozotocin (30 mg/kg, ip). Animals were randomly divided into 3 groups: control rats, untreated diabetic rats that received vehicle and treated diabetic rats that received Rho-kinase inhibitor fasudil hydrochloride hydrate (10 mg·kg-1·d-1, ip, for 14 weeks). Cardiac contractile function… CONTINUE READING
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