Involvement of Renal Corpuscle microRNA Expression on Epithelial-to-Mesenchymal Transition in Maternal Low Protein Diet in Adult Programmed Rats

@inproceedings{Sene2013InvolvementOR,
  title={Involvement of Renal Corpuscle microRNA Expression on Epithelial-to-Mesenchymal Transition in Maternal Low Protein Diet in Adult Programmed Rats},
  author={Let{\'i}cia de Barros Sene and Fl{\'a}via Fernandes Mesquita and Leonardo Naz{\'a}rio de Moraes and Daniela Carvalho Dos Santos and Robson Francisco Carvalho and Jos{\'e} A R Gontijo and Patricia A Boer},
  booktitle={PloS one},
  year={2013}
}
Prior study shows that maternal protein-restricted (LP) 16-wk-old offspring have pronounced reduction of nephron number and arterial hypertension associated with unchanged glomerular filtration rate, besides enhanced glomerular area, which may be related to glomerular hyperfiltration/overflow and which accounts for the glomerular filtration barrier breakdown and early glomerulosclerosis. In the current study, LP rats showed heavy proteinuria associated with podocyte simplification and foot… CONTINUE READING
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