Involvement of Ral GTPase in v-Src-induced phospholipase D activation

  title={Involvement of Ral GTPase in v-Src-induced phospholipase D activation},
  author={Hong Jiang and Jing-Qing Luo and Takeshi Urano and Paul Frankel and Zhimin Lu and David A. Foster and Larry A. Feig},
AN early response to the tyrosine kinase activity of v-Src is an increase in phospholipase D (PLD) activity1, which leads to the generation of biologically active lipid second messengers, including phosphatidic acid, lysophosphatidic acid and diacylglycerol2. We have recently demonstrated that v-Src-induced PLD activity is mediated by Ras3, although Ras involvement was indirect, requiring a cytosolic factor for PLD activation3. Ras interacts with4–6 and activates Ral–GDS13, the exchange factor… CONTINUE READING


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