Involvement of Rad18 in somatic hypermutation.

@article{Bachl2006InvolvementOR,
  title={Involvement of Rad18 in somatic hypermutation.},
  author={Juergen Bachl and Isin Ertongur and Berit Jungnickel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 32},
  pages={
          12081-6
        }
}
Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig loci. Error-prone processing of the resultant DNA lesions is thought to cause extensive mutagenesis, but it is presently an enigma how and why error-prone rather than error-free repair pathways are recruited. During DNA replication, recruitment of error-prone translesion polymerases may be mediated by Rad6/Rad18-mediated ubiquitination of proliferating cell nuclear antigen, a major switchboard… CONTINUE READING

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