Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B.

@article{Bompard2005InvolvementOR,
  title={Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B.},
  author={Guillaume Bompard and Stewart J Sharp and Gilles Freiss and Laura M Machesky},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 22},
  pages={5393-403}
}
Numerous scaffold proteins coordinate signals from the environment with actin-based protrusions during shape change and migration. Many scaffolds integrate signals from Rho-family GTPases to effect the assembly of specific actin structures. Here we investigate the mechanism of action MIM-B (missing in metastasis-B) on the actin cytoskeleton. MIM-B binds actin monomer through a WASP homology 2 motif, bundles actin filaments via an IRSp53/MIM domain, and is a long isoform of MIM, a proposed… CONTINUE READING