Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage.

Abstract

Neutrophil-induced coronary microvascular barrier dysfunction is an important pathophysiological event in heart disease. Currently, the precise cellular and molecular mechanisms of neutrophil-induced microvascular leakage are not clear. The aim of this study was to test the hypothesis that rho kinase (ROCK) increases coronary venular permeability in… (More)

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