Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a Vaccinia virus recombinant

Abstract

Hepatitis C virus (HCV) infection is of growing concern in public health with around 350 million chronically infected individuals worldwide. Although the IFN-α/rivabirin is the only approved therapy with 10–30% clinical efficacy, the protective molecular mechanism involved during the treatment is still unknown. To analyze the effect of HCV polyprotein… (More)
DOI: 10.1186/1743-422X-2-81

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@article{Gmez2005InvolvementOP, title={Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a Vaccinia virus recombinant}, author={Carmen Elena G{\'o}mez and Andr{\'e}e Marie Vandermeeren and Mar{\'i}a {\'A}ngel Garc{\'i}a and Elena Domingo-Gil and Mariano Est{\'e}ban}, journal={Virology Journal}, year={2005}, volume={2}, pages={81 - 81} }