Involvement of PKC and PKA in the inhibitory effect of leptin on intestinal galactose absorption.

@article{Barrenetxe2004InvolvementOP,
  title={Involvement of PKC and PKA in the inhibitory effect of leptin on intestinal galactose absorption.},
  author={Jaione Barrenetxe and Neira S{\'a}inz and Ana Barber and Mar{\'i}a Pilar Lostao},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={317 3},
  pages={717-21}
}
Studies from our laboratory have demonstrated that leptin inhibits galactose absorption in vitro by acting on the Na(+)/glucose cotransporter SGLT1. Since PKC and PKA are involved in the regulation of SGLT1 and leptin is able to activate these kinases, we have investigated the possible implication of PKC and PKA in the inhibition of sugar absorption by leptin in rat small intestinal rings. Inhibition of 1 mM galactose uptake by 0.2 nM leptin is blocked by 2 microM chelerythrine, a PKC inhibitor… CONTINUE READING

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