Involvement of PKC-alpha in PDGF-mediated mitogenic signaling in human mesangial cells.

@article{Choudhury1993InvolvementOP,
  title={Involvement of PKC-alpha in PDGF-mediated mitogenic signaling in human mesangial cells.},
  author={Goutam Ghosh Choudhury and Priscilla Biswas and Giuseppe Grandaliano and Hanna Emily Abboud},
  journal={The American journal of physiology},
  year={1993},
  volume={265 5 Pt 2},
  pages={F634-42}
}
Platelet-derived growth factor (PDGF) is a potent mitogen for a variety of cells. The calcium/phospholipid-dependent protein kinase C (PKC) represents a major signal transduction pathway for many growth stimuli including PDGF. Various isoforms of PKC are differentially expressed in the same or in different cells and tissues, and diverse stimuli may selectively activate one or more PKC isoforms. We studied the effect of PDGF on DNA synthesis and on the activity of PKC in human mesangial cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…