Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons.

@article{Bailey2009InvolvementOP,
  title={Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons.},
  author={Christopher Philip Bailey and S. D. Oldfield and Javier Llorente and Christopher James Caunt and Anja G Teschemacher and Lou A Roberts and Craig Alexander McArdle and Forrest L. Smith and William L. Dewey and Eamonn Kelly and Graeme Henderson},
  journal={British journal of pharmacology},
  year={2009},
  volume={158 1},
  pages={157-64}
}
BACKGROUND AND PURPOSE The ability of an agonist to induce desensitization of the mu-opioid receptor (MOR) depends upon the agonist used. Furthermore, previous data suggest that the intracellular mechanisms underlying desensitization may be agonist-specific. We investigated the mechanisms underlying MOR desensitization, in adult mammalian neurons, caused by morphine (a partial agonist in this system) and DAMGO (a high-efficacy agonist). EXPERIMENTAL APPROACH MOR function was measured in locus… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Agonist-selective mechanisms of GPCR desensitisation

  • E Kelly, CP Bailey, G Henderson
  • Br J Pharmacol 153 (Suppl
  • 2007
2 Excerpts

Similar Papers

Loading similar papers…