Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice.

@article{Cunha2014InvolvementOP,
  title={Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice.},
  author={Mauricio P Cunha and Josiane Budni and Francis Leonardo Pazini and {\'A}gatha Oliveira and Julia Macedo Rosa and Mark William Lopes and Rodrigo Bainy Leal and Ana L{\'u}cia S Rodrigues},
  journal={Pharmacological reports : PR},
  year={2014},
  volume={66 4},
  pages={653-9}
}
BACKGROUND The aim of this study was to investigate the involvement of signaling pathways on the creatine antidepressant-like effect in the tail suspension test (TST) in mice. METHODS The TST was used to assess the antidepressant-like properties of creatine. RESULTS The anti-immobility effect of creatine (1mg/kg, p.o.) in the TST was blocked by i.c.v. pretreatment with H-89 (1μg/site, PKA inhibitor), KN-62 (1μg/site, CAMK-II inhibitor), chelerythrine (1μg/site, PKC inhibitor), U0126 (5μg… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

A randomized, doubleblind placebo-controlled trial of oral creatine monohydrate augmentation for Please cite this article in press

  • IK Lyoo, S Yoon, TS Kim, J Hwang, JE Kim, W Won
  • Pharmacol Rep
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…