Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages.

@article{DazMuoz2012InvolvementOP,
  title={Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages.},
  author={Manuel D D{\'i}az-Mu{\~n}oz and In{\'e}s C Osma-Garc{\'i}a and Manuel Rivas del Fresno and Miguel Angel I{\~n}iguez},
  journal={The Biochemical journal},
  year={2012},
  volume={443 2},
  pages={451-61}
}
PG (prostaglandin) E2 plays an important role in the modulation of the immune response and the inflammatory process. In the present study, we describe a PGE2 positive feedback for COX (cyclo-oxygenase)-2 and mPGES-1 [microsomal PGES (PGE synthase)-1] expression in the macrophage cell line RAW 264.7. Our results show that PGE2 induces COX-2 and mPGES-1 expression, an effect mimicked by dbcAMP (dibutyryl-cAMP) or forskolin. Furthermore, the cAMP signalling pathway co-operates with LPS… CONTINUE READING
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