Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines.

  title={Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines.},
  author={Aiwu Cheng and Ruiqian Wan and Jenq-Lin Yang and Naomi Kamimura and Tae Gen Son and Xin Ouyang and Yongquan Luo and Eitan Okun and Mark P. Mattson},
  journal={Nature communications},
The formation, maintenance and reorganization of synapses are critical for brain development and the responses of neuronal circuits to environmental challenges. Here we describe a novel role for peroxisome proliferator-activated receptor γ co-activator 1α, a master regulator of mitochondrial biogenesis, in the formation and maintenance of dendritic spines in hippocampal neurons. In cultured hippocampal neurons, proliferator-activated receptor γ co-activator 1α overexpression increases dendritic… CONTINUE READING
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