Involvement of PDX-1 in activation of human insulin gene transcription.

  title={Involvement of PDX-1 in activation of human insulin gene transcription.},
  author={John Le Lay and Roland Stein},
  journal={The Journal of endocrinology},
  volume={188 2},
Islet beta cell-specific transcription of the insulin gene is mediated through the binding of the islet-enriched PDX-1, BETA2, and MafA transcription factors to conserved 5'-flanking region regulatory elements. However, additional non-conserved sequences within this region are also significant in regulating expression. Thus, PDX-1 binds to and activates the GG2 element located between nucleotides -145 and -140 of the human gene, while the corresponding, but non-identical, site in the rodent… CONTINUE READING
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Identification of a novel PDX-1 binding site in the human insulin gene enhancer

  • J Le Lay, TA Matsuoka, E Henderson, R Stein
  • Journal of Biological Chemistry
  • 2004
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