Involvement of Notch signaling in initiation of prechondrogenic condensation and nodule formation in limb bud micromass cultures

@article{Fujimaki2005InvolvementON,
  title={Involvement of Notch signaling in initiation of prechondrogenic condensation and nodule formation in limb bud micromass cultures},
  author={Ryoji Fujimaki and Yoshiaki Toyama and N. Hozumi and Ken-ichi Tezuka},
  journal={Journal of Bone and Mineral Metabolism},
  year={2005},
  volume={24},
  pages={191-198}
}
Notch signaling is an evolutionarily conserved mechanism that plays a critical role in the determination of multiple cellular differentiation pathways and morphogenesis during embryogenesis. The limb bud high-density culture is an established model that recapitulates mesenchymal condensation and chondrocyte differentiation. Reverse transcription-polymerase chain reaction (RT-PCR) showed that Notch and its related genes were expressed in such cultures on day 1 and reached a peak between day 3… CONTINUE READING

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