Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes.

  title={Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes.},
  author={Lijun Leo Liu and Jie Li and Jiang Liu and Zhaokai Yuan and Sandrine V. Pierre and Weikai Qu and Xiaochen Zhao and Zijian Xie},
  journal={Free radical biology & medicine},
  volume={41 10},
We have shown that increased production of reactive oxygen species (ROS) was required for ouabain-induced hypertrophy in cultured cardiac myocytes. In the present study we assessed whether long-term exposure of myocytes to nontoxic ROS stress alone is sufficient to induce hypertrophy. A moderate amount of H2O2 was continuously generated in culture media by glucose oxidase. This resulted in a steady increase in intracellular ROS in cultured cardiac myocytes for at least 12 h. Such sustained, but… CONTINUE READING
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Studies on the specificity of the effects of oxygen metabolites on cardiac sodium

  • Z. J. Xie, Y. H. Wang, A Askari
  • pump. J. Mol. Cell. Cardiol
  • 1990
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