Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes.

  title={Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes.},
  author={L. Liu and J. Li and J. Liu and Zhaokai Yuan and S. Pierre and W. Qu and X. Zhao and Z. Xie},
  journal={Free radical biology & medicine},
  volume={41 10},
  • L. Liu, J. Li, +5 authors Z. Xie
  • Published 2006
  • Chemistry, Medicine
  • Free radical biology & medicine
  • We have shown that increased production of reactive oxygen species (ROS) was required for ouabain-induced hypertrophy in cultured cardiac myocytes. In the present study we assessed whether long-term exposure of myocytes to nontoxic ROS stress alone is sufficient to induce hypertrophy. A moderate amount of H2O2 was continuously generated in culture media by glucose oxidase. This resulted in a steady increase in intracellular ROS in cultured cardiac myocytes for at least 12 h. Such sustained, but… CONTINUE READING
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    Publications referenced by this paper.
    Intracellular Reactive Oxygen Species Mediate the Linkage of Na+/K+-ATPase to Hypertrophy and Its Marker Genes in Cardiac Myocytes*
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